Virus Variability, Epidemiology and Control PDF
By:Edouard Kurstak,R.G. Marusyk,F.A. Murphy,M.H.V. Van Regenmortel
Published on 1990-09-30 by Springer Science & Business Media
Virus Variability and Impact on Epidemiology and Control of Diseases E. Kurstak and A. Hossain I. INTRODUCTION An important number of virus infections and their epidemic developments demonstrate that ineffec tiveness of prevention measures is often due to the mutation rate and variability of viruses (Kurstak et al., 1984, 1987). The new human immunodeficiency retroviruses and old influenza viruses are only one among several examples of virus variation that prevent, or make very difficult. the production of reliable vaccines. It could be stated that the most important factor limiting the effectiveness of vaccines against virus infections is apparently virus variation. Not much is, how ever, known about the factors influencing and responsible for the dramatically diverse patterns of virus variability. II. MUTATION RATE AND VARIABILITY OF HUMAN AND ANIMAL VIRUSES Mutation is undoubtedly the primary source of variation, and several reports in the literature suggest that extreme variability of some viruses may be a consequence of an unusually high mutation rate (Holland et al., 1982; Domingo et al., 1985; Smith and Inglis, 1987). The mutation rate of a virus is defined as the probability that during a single replication of the virus genome a particular nucleotide position is altered through substitution, deletion, insertion. or recombination. Different techniques have been utilized to measure virus mutation rates, and these have been noted in the extent of application to different viruses.
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Book ID of Virus Variability, Epidemiology and Control's Books is 8IqP-MqI36MC, Book which was written byEdouard Kurstak,R.G. Marusyk,F.A. Murphy,M.H.V. Van Regenmortelhave ETAG "FseVgE4C44U"
Book which was published by Springer Science & Business Media since 1990-09-30 have ISBNs, ISBN 13 Code is 9780306433597 and ISBN 10 Code is 0306433591
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